Possibly the best lecture I've seen (well, viewed). This us from the Carnegie Mellon Journeys Lecture series. Randy Pausch is an amazing man, stricken with pancreatic cancer and will not be alive in a few months from now. What he says in this video really makes you take a good look at how your outlook on life can change what is important to you and what you make of the things you have been denied of in the past, how to grow from that.

Windows streaming video

Google video

The video is about 1 hour long.

It may not work for you. so click on this link to go to the site: http://cmu.edu/uls/journeys/